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For neurological CNS biology research, note that Semaglutide has limited blood-brain barrier penetration relative to smaller CNS-active peptides , intracerebroventricular administration routes may be required for studies examining direct central GLP-1R biology independently of peripheral-to-central signalling mechanisms

Crockett Chair in Diabetes Research, medical director of AdventHealth Diabetes Institute and a Healio | Endocrine Today Co-editor, described the FLOW findings as practice changing. Pratley said while the American Diabetes Association Standards of Care recommends SGLT2 inhibitors as the first-line treatment for most adults with type 2 diabetes and CKD, the FLOW trial may change that in the future

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